Selected Publications (from more than 150 publications in total)
1. Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T*. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Molecular Cell, 5/2002, 9(5):945-56, (Highlighted by Nature Review Mol Cell Biol 2002;3:473; Nature-Signaling Update/the signaling gateway, 2002; and Faculty of 1000 Biology).
2. Lu Z*, Ghosh S, Wang Z, Hunter T*. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell, 12/2003, 4(6):499-515 (Highlighted by Nature Review Cancer 2004; 4:90-91; Nature Signaling & Update/The signaling gateway 2004, and Faculty of 1000 Biology).
3. Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z*. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. (Highlighted by Faculty of 1000 Biology; Selected as the feature article by Molecular Cell and received MDACC Nycomed GmbH Outstanding Research Publication Award in 2007). Molecular Cell, 1/2007, 25(2):219-32. PMCID: PMC1829326.
4. Lu Z*, Hunter T*. Degradation of activated protein kinases by ubiquitination. Annual Review Biochemistry, 7/2009, 78:435-75. PMCID: PMC2776765.
5. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, Zhou X, Aldape K, Cobb M, Xie K, He J, and Lu Z*. FAK phosphorylation by ERK primes Ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Molecular Cell, 7/2009, 35(1):11-25 (Highlighted by Molecular Cell and Faculty of 1000 Biology). PMCID: PMC2715139.
6. Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z*. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Molecular Cell, 11/2009, 36(4):547-59 (Selected as the feature article by Molecular Cell and highlighted by Cell and M.D. Anderson News Release). PMCID: PMC2784926.
7. Yang W, Xia X, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z*. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature, 12/2011 480(7375):118-22, PMID: 22056988 (2011 Outstanding Research Publication Award at MD Anderson; Highlighted by Cell, Nature SciBX, Science Signaling, Cancer Research, Cell Research, Chinese journal of Cancer, Future Oncology, and Faculty of 1000 Biology, and M.D. Anderson News Release).
8. Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z*. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell, 8/2012; 150 (4): 685-696 (Listed in 2012: Signaling Breakthroughs of the Year, Science Signaling;Highlighted by Cell, Nature Reviews Cancer, Cancer Discovery, Cell Cycle, Faculty of 1000 Biology, and M.D. Anderson News Release).
9. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You M, Koh M, Cote G, Aldape K, Li Y, Verma I, Chiao P, and Lu Z*. EGFR-induced and PKCe monoubiquitylation-dependent NF-kB activation upregulates PKM2 expression and promotes turmorigenesis. Molecular Cell, 12/2012; 48(5):771-84 PMID:23123196 (Highlighted by Cancer Discovery and M.D. Anderson News Release)
10. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis C, Aldape K, Cantley L, and Lu Z*. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology, 12/2012;14(12):1295-304, PMID:23178880 (Highlighted in Nature Review Cancer 13, 5, 2013; Nature Chemical Biology; Cell Cycle and M.D. Anderson News Release)
11. Jiang Y, Li X, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, and Lu Z*. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Molecular Cell, 1/2014. 53(1):75-87. PMID: 24316223 (Highlighted by Cancer Discovery and M.D. Anderson News Release).
12. Lu Z* and Hunter T*. Prolyl isomerase PIN1 in cancer. Cell Research. 2014. (9):1033-49. PMID: 25124924.
13. Jiang Y, Wang Y, Wang T, Hawke D, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu D, Huang S, and Lu Z*. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells. Nature Communications. 11/2014. 5:5566. (Highlighted by M.D. Anderson News Release).
14. Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li G, Yang J, Li X, Lu Z, and Liu D*. ATF5 connects the pericentriolar material to the proximal end of the mother centriole in the centrosome. Cell, 7/2015. 162(3):580-92. PMID: 26213385.
15. Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin S, and Lu Z*. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biology, 9/2015.7(9):1158-68. PMID: 26237645. (Highlighted in Nature Cell Biology, Cancer Discovery, Science Signaling, and an MD Anderson news release).
16. Zheng Y, Li X, Qian X, Wang Y, Lee J, Xia Y, Hawke D, Zhang G, Lu J, and Lu Z*. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nature Cell Biology, 10/2015. 17(10):1348-55. PMID: 26280537 (Highlighted by Cancer Discovery, Science Signaling, and an MD Anderson news release).
17. Ji H, Lee J, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z*. EGFR phosphorylates FAM129B to promote Ras activation. PNAS. 1/2016. 113(3):644-9. PMID:26721396.
18. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, and Lu Z*. Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis. Molecular Cell. 3/2016. 61(5):705-719. PMID:26942675. (highlighted by MD Anderson news release).
19. Li X, Qian X, Peng L, Jiang Y, Hawke D, Zheng Y, Xia Y, Lee J, Cote G, Wang H, Wang L, Qian C, and Lu Z*. A Splicing Switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology, 5/2016. 18(5):561-71. PMID:2708854. (Highlighted by Cancer Discovery, Science Signaling, and an MD Anderson news release).
20. Liang J, Cao R, Zheng Y, Xia Y, Zheng Y, Li X, Wang L, Yang W* and Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 8/2016, 7:12431. PMID: 27485204
21. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z*. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Molecular Cell. 3/2017, 2;65(5):917-931.PMID: 28238651 (Highlighted by Autophagy and an MD Anderson news release).
22. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, and Lu Z*. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. The Journal of Experimental Medicine. 6/2017. 214 (6), 1843-1855. PMID:28507061.
23. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, Li W, Lyu J, Rao G, Zhang X, Qian C, Rozen S, Jiang T, Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell. 6/2017;66(5):684-697. PMID:28552616. (Highlighted by Nature Reviews Molecular Cell Biology and an MD Anderson news release).
24. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, Groot J, Tao Jiang T, Lu Z*. Stabilization of Phosphofructokinase 1 Platelet Isoform by AKT Promotes Tumorigenesis. Nature Communications. 10/2017; 16;8(1):949. doi: 10.1038/s41467-017-00906-9. PMID: 29038421
25. Wang Y,Guo Y, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee J, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J He J, Xing D*, Tao Y*, Lu Z*. KAT2A Coupled with the a-KGDH Complex Acts as a Histone H3 Succinyltransferase. Nature, 12/2017. 552(7684):273-277. PMID: 29211711 (Highlighted by Cancer Discovery, Faculty of 1000 Prime, and an MD Anderson news release).
26. Qian X, Li X, Tan L, Lee JH, Xia X, Cai Q, Zheng Y, Wang H, Lorenzi P, Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery, 1/2018: 8(1):94-107. PMID: 29074724.
27. Lu Z* and Hunter T*. Metabolic Kinases Moonlighting as Protein Kinases. Trends in Biochemical Sciences. 4/2018. (4):301-310. PMID: 29463470.
28. Lee JH, Liu R, Li J., Wang YG, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng y, Chen Q, Lorenzi PL, Mills GB, Jiang T, and Lu Z*. EGFR-phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Molecular Cell, 4/2018 Apr 19;70(2):197-210. PMID: 29677490
29. Li X, Egervari G, Wang Y, Berger SL*, Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology. 9/2018.19(9):563-578. PMID: 29930302
30. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Molecular Cell, 11/2018. 72 (4): 650-660. PMID: 30392930.
31. Xu D, Li X, Shao F, Lv G, Lv H, Lee J, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H*, Lyu J* and Lu Z*. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances, 4/2019. 5 (4): eaav4570. PMID: 31032410.
32. Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z*, Hongxia Wang* (* Co-corresponding). TSPAN8 Promotes Cancer Cell Stemness via Activation of Sonic Hedgehog Signaling. Nature Communications, 6/2019. 10(1):2863. PMID: 31253799.
33. Qian X*, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L,Zheng Y, Zhao D, Zhang C, Lorenzi P, You Y, Jiang B, Jiang T, Li H, and Lu Z*. PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1. Molecular Cell, 11/2019. 76(3):516-527. PMID: 31492635.
34. Xie Y, Lv X, Ni D, Liu J, Hu Y, Liu Y, Liu Y, Liu R, Zhao H, Lu Z*, Zhou Q*(*Co-corresponding). HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Nature Communications, 9/2019. 10(1):4266. PMID: 31537781.
35. Qian X*, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Molecular Cell, 12/2019. 76(6):885-895. PMID:31629659
36. Li X*, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, Depinho R, and Lu Z*. Programmable base editing of mutated TERT promoter inhibits tumor growth. Nature Cell Biology, 2/2020. PMID: 32066906 (Highlighted by Nature Cell Biology, Cancer Research, and Faculty of 1000 Prime).
37. Xu D*, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee J, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung M*, and Lu Z*. Gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature, 4/2020. 580(7804):530-535. PMID: 32322062.
38. Du L, Lee J, Jiang H, Wang C, Wang S, Zheng Z, Shao F, Xu X, Xia Y, Li J, Zheng Z, Xu Qian X, Li X, Kim H, Xing D, Liu P, Lu Z*, and Lyu J* (* Co-corresponding). b-catenin induces transcriptional expression of PD-L1 to promote tumor immune evasion. Journal of Experimental Medicine, 2020. 217(11):e20191115. PMID: 32860047. (Highlighted in Journal of Experimental Medicine and Rockefeller University News Release).
39. Bian X, Liu R, Meng Y, Xing D*, Xu D*, and Lu Z*. Lipid metabolism and cancer. Journal of Experimental Medicine, 2021. 218 (1): e20201606.
40. Xu D, Shao F, Bian X, Meng Y, Liang T, and Lu Z*. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies. Cell Metabolism, 1/2021. 33(1):33-50. PMID: 33406403.
41. Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Guo D, Sun Y, Wang J2, Xue Q, Gao S, Gao Y, He J, and Lu Z. METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding. Nature Communications, 6/2021. 12(1):3803. PMID: 34155197.
42. Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R*, and Lu Z*. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress of tumor cells. Molecular Cell, 6/2021, 81(11):2303-2316. PMID: 33991485
43. Liu R*, Lee JH, Yu R, Li J, Tan L, Xia Y, Zheng Y, Bian X, Lorenzi P, Chen Q,* and Lu Z *. Choline kinase alpha 2 acts as a protein kinase to promote the lipolysis of lipid droplets. Molecular Cell, 2021. 7/2021. 81(13):2722-2735. PMID: 34077757 (Highlighted in Molecular Cell).
44. Zhao JS, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu X, Feng L, Shi Z, Krakowiak J, Mao RY, Shen YT, Fan YM, Fu TM, Ye C, Xu D, Gao X, You J, Li W, Liang T, Lu Z *, Feng YX*.Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth. Nature Metabolism, 2022. 4(2):239-253. doi: 10.1038/s42255-021-00524-2. PMID: 35145325
45. Bian X, Jiang H, Meng Y, Li YP, Fang J, Lu Z. Regulation of gene expression by glycolytic and gluconeogenic enzymes. Trends Cell Biol. 2022 Mar 14:S0962-8924(22)00036-8. doi: 10.1016/j.tcb.2022.02.003. PMID: 35300892.
46. Guo D, Tong Y, Jiang X, Meng Y, Jiang H, Du L, Wu Q, Li S, Luo S, Li M, Xiao L, He H, He X, Yu Q, Fang J, Lu Z. Aerobic glycolysis promotes tumor immune evasion by hexokinase 2-mediated phosphorylation of IkBa. Cell Metabolism, 2022. Sep 6;34(9):1312-1324.e6. doi: 10.1016/j.cmet.2022.08.002. Epub 2022 Aug 24. PMID: 36007522 (Highlighted in Cancer Discovery).
47. Shao F， Gao Y， Wang W， He H, Xiao L, Geng X, Xia Y, Guo D, Fang J, He J, Lu Z. Silencing EGFR-upregulated expression of CD55 and CD59 activates complement system and sensitizes lung cancer to immune checkpoint blockade therapy. Nature Cancer, 2022. Oct;3(10):1192-1210. doi: 10.1038/s43018-022-00444-4. Epub 2022 Oct 21. PMID: 36271172 (Cover story, highlighted in Nature Cancer and Science Signaling).
48. Wang Z, Li M, Jiang H, Luo S, Shao F, Xia Y, Yang M, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Liang T, Yu R, Xu D, and Lu Z. Fructose-1,6-bisphosphatase 1 acts as a protein phosphatase to dephosphorylate histone H3 and regulate gene transcription. Nature Cell Biology, 2022. 4(11):1655-1665. doi: 10.1038/s41556-022-01009-4. Epub 2022 Oct 20. PMID: 36266488 (Highlighted by Nature Cell Biology).
49. Liu T, Wang Z, Ye L, Duan Y, Jiang H, He H, Xiao L, Wu Q, Xia Y, Yang M, Wu K, Yan M, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Shao F, Qian X, Yu R, Zhang Z, Lu Z*, Xu D*. Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nature Cell Biology, 2023; Feb;25(2):273-284.doi: 10.1038/s41556-022-01061-0. Epub 2023 Jan 16. PMID: 36646788.
50. Zhang G, Tao J, Lin L, Qiu W, Lu Z. Repurposing FBP1: dephosphorylating IκBα to suppress NFκB. Cell Research. 2023 Jun;33(6):419-420. doi: 10.1038/s41422-023-00785-4. PMID: 36828939
51. Fang J, Luo S, Lu Z. HK2: Gatekeeping microglial activity by tuning glucose metabolism and mitochondrial functions. Molecular Cell, 2023 Mar 16;83(6):829-831. doi: 10.1016/j.molcel.2023.02.022. PMID: 36931254.
52. Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q, Lu Z*, Xu D*. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nature Cell Biology, 2023; May;25(5):714-725. doi: 10.1038/s41556-023-01133-9. PMID: 37156912 (Highlighted by Nature Cell Biology).
53. Ma Q, Jiang H, Ma L, Zhao G, Xu Q, Guo D, He N, Liu H, Meng Z, Liu J, Zhu L, Lin Q, Wu X, Li M, Luo S, Fang J, Lu Z. The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2209435120. doi: 10.1073/pnas.2209435120. PMID: 37011206.
54. Yin J, Wang X, Ge X, Ding F, Shi Z, Ge Z, Huang G, Zhao N, Chen D, Zhang J, Agnihotri S, Cao Y, Ji J, Lin F, Wang Q, Zhou Q, Wang X, You Y, Lu Z*, Qian X*. Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. Nature Communications. 2023 Sep 22;14(1):5913. doi: 10.1038/s41467-023-41663-2. PMID: 37737247
55. Du L, Su Z, Wang S, Meng Y, Xiao F, Xu D, Li X, Qian X, Lee SB, Lee JH*, Lu Z*, Lyu J*. EGFR-Induced and c-Src-Mediated CD47 Phosphorylation Inhibits TRIM21-Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion. Advanced Sciences. 2023 Aug 4:e2206380. doi: 10.1002/advs.202206380. PMID: 37541303
56. Thompson CB, Vousden KH, Johnson RS, Koppenol WH, Sies H, Lu Z, Finley LWS, Frezza C, Kim J, Hu Z, Bartman CR. A century of the Warburg effect. Nature Metabolism. 2023 Nov;5(11):1840-1843. doi: 10.1038/s42255-023-00927-3. PMID: 37990075
57. Wang Z, Ma L, Meng Y, Xu D, and Lu Z. The interplay of the circadian clock and metabolic tumorigenesis. Trends Cell Biol. 2023. PMID: 38061936
58. Wang Z, Yan M, Ye L, Zhou Q, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B, Lu Z*, Xu D*. VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. EMBO J. 2024 Mar;43(6):931-955. doi: 10.1038/s44318-024-00051-2. Epub 2024 Feb 15. PMID: 38360997
59. Zhao G, Ma Q, Yang H, Jiang H, Xu Q, Luo S, Meng Z, Liu J, Zhu L, Lin Q, Li M, Fang J, Ma L, Qiu W, Mao Z, Lu Z. Base editing of the mutated TERT promoter inhibits liver tumor growth. Hepatology. 2023 Nov 28. PMID: 38016019
60. Li M, Wang Z, Tao J, Jiang H, Yang H, Guo D, Zhao H, He X, Luo S, Jiang X, Yuan L, Xiao L, He H, Yu R, Fang J, Liang T, Mao Z, Xu D, Lu Z. Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Nature Chemical Biology. 2024 Mar 27. doi: 10.1038/s41589-024-01597-2. PMID: 38538923.
61. Wang, J, Yang Y, Shao F, Meng Y, Guo D, He J, Lu, Z. Acetate reprograms tumor metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc. Nature Metabolism. 2024 May 3. doi: 10.1038/s42255-024-01037-4. PMID: 38702440.
62. Meng Y, Guo D, Lin L, Zhao H, Xu W, Luo S, Jiang X, Li S, He X, Zhu R, Shi R, Xiao L, Wu Q, He H, Tao J, Jiang H, Wang Z, Yao P, Xu D, Lu Z. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance β-oxidation and tumor cell proliferation. Nature Metabolism. 2024. May 21. PMID: 38773347. DOI: 10.1038/s42255-024-01047-2.
